Today I decided to play with the M&D ME05 buds at my desk, using my desk stack (Asgard 3 + Redscape) and dug out the Creative G6, and did some gaming on both. One of the first things I discovered is don't use these IEMs on High Gain of the G6, as the bass levels get BOOMY fast. The G6 and SBX actually do a very good job with these, as I was able to hunt down critters in Diablo II Resurrected easily by positional audio, and those horns blowing in Town... HA.
The smooth presentation of the ME05 mate well with the somewhat grainy output of the G6, and conceal this flaw nicely, to the point that I don't notice it much. It hits me in the face when driving the DT-1990 / M1570. So maybe it's a matching issue. The ME05 mic also works rather well being a shirt-clip mic, and the TRRS plug works with the G6 for feeding the mic to the unit. Also, the G6 doesn't get hot driving these IEMs, as opposed to my power hungry cans.
The Asgard 3 has no problem with these IEMs using Low Gain on the A3, and no issues with frequency response or any imbalances. In the end, the ME05 make for great IEMs to game on, and watch movies with. Bass is not shy on these w/o being bloated, and I find the stock tuning to be spot on, so EQ isn't required.