I've heard the 5LEs and the 6s. The 4s are supposed to be exactly the same as the 5LEs except less efficient because they have fewer magnets in them though I don't know how this holds up sound wise. They're both a little bright for my tastes (I'd go for the LCD-2 if I could get much use out of an open 'phone), but I'm pretty sensitive to treble. They're hardly ear piercers like the Beyer DT990s or something though. I've come to like Orthos because they have speed, extension, and smoothness that doesn't sacrifice any detail. IMO, only a few dynamic 'phones really compete (or might if I got further listening) with orthos in those departments.
A few people come away with a completely different impression though. They don't just not find them to their tastes, which is reasonable and easily understandable, but describe their sound completely differently than most people so they aren't exactly a sure thing.
For genre bandwidth, I can really only speak to my more preferred genres lest I sound like a pompous "classical snob" who complains about things I don't know much about. They are fast, detailed, transparent, and have very good tonality which should make them good with that but I couldn't say for sure since I don't listen to a ton. Those traits do make them great with metal though. Death metal blast beats aren't muddied, the occasional synth, keyboard, piano, or pan flute will come through unmolested by the heaviest guitars, solo shreds retain all their detail, and operatic female vocals are lush and ephemeral without smoothing over any harshness from growls and screams. For electronica, all of the new ones seem to go low enough for deepest synthesized notes along with good imaging and phase coherency for the sort of crazy effects that move all over the place.