Checking back in after a couple days:
The change wasn't earth-shattering, as others have said. I did cut out the annoying hiss that was present on my onboard headphone jack, so there's that. I didn't hear too much of a difference between the amp and the onboard audio in terms of normal SQ other than additional clarity, but I didn't have huge expectations. I have an '08 aluminum macbook, to give more info on my setup.
On the amp side: I still get the pops between tracks and the buzz when the pot is up too high. Checked on two other computers and all my ports.
As I posted before, I have some interference issues with Netflix, where the sound clips for about 20 seconds at a time. Sometimes the end of my songs on itunes cut off at the last 5 seconds or so before changing tracks, making the pop more apparent. (Yes, I've done the usual checks of end-time/start time).
It's not an issue with the DAC, but with the amp, so I'm not sure if it's a this-e10-is-a-lemon problem or if there's an impedance conflict between my headphones (I've got Grado 80s and 220s [borrowed] and sennheiser iems, all with ~32ohms) that I have to resolve.
As far as the DAC-Only output: It was clean, attenuated, with none of the buzzing or sound issues that were present on the amp line. But the OS volume has to be at least 75% otherwise it would sound dim. Line out on the DAC side definitely needs an amp. With the proper levels, I am impressed, as the DAC's the clearest I've heard my music.
So there's the rub. Love the DAC, not happy with the amp for now. Not sure if I should just stick with a d5 (the chips are similar enough, right?) and use a different amp, like a cmoy, if it's the e10, or just some software settings I have to fix.