I don't have any data related to (1), sorry. We have good track record with our battery suppliers. So far our previous DAP batteries can live up with the 2 years or 300-500 charging cycle (whichever occurs first) norm and is e have encountered cases that sustain beyond that.
(3) The N6ii use Qualcomm solution so it is fully compatible with QC3.0, so this question is more related to generic lithium battery care taking under QC3.0 rather then N6ii only. In short, this will depends on your charger, some charger will cut off the charging when the charging current drop down to certain level, some won't. In most cases, it won't damage your battery immediately but will stressed the battery in the long run. If you are concerned about the battery life, shallow discharges and recharges are better than full charging cycle, because they put less stress on the battery, so it lasts longer. Regular full discharges or repeatedly charge up to 100% will speed up the aging of the battery. I always advice my users to stay within 20%-80% of battery range. I'll avoid battery drain to 10% or below, and I set countdown alarm to unplug my DAP from charger between 80% -90%. You can refer to other lithium battery discussion
HERE,
HERE and
HERE.
In fact, that's why our Sales material stated the reference charging time of N6ii is 110 mins from 10% to 90%. We want to encourage users to stay within this range instead of charging the player to 100%.
(4) Our officially recommendation is to avoid charging and playing music simultaneously. Not that it is unsafe or the battery will explode, but this will stressed the power supply components as the internal currents will increase substantially. If you are playing regular CD quality FLAC, you probably won't aware of the that because the heat dispensation can still take care of it effectively, but when you playback high sample rate tracks, you'll feel the temperature.
My N6ii was on loan to a local reviewer, so I passed Question (2) to our Engineer and Cayinsupport will come back to you later.