I've just gone through a little bit of a personal adventure with an attempt at improving audio over USB. Tried out external USB to S/PDIF converters, IFI iUSB, Batteries, fancy split cables, all of the usual stuff. I ended up removing the LED lights from my computer and getting rid of any wall warts in my listening room that were not completely necessary. I learned quite a bit really and did manage to improve the sound I was getting, but not in the way I had expected.
After all of that, I ended up with just a short .5m USB cable running from my computer to my DAC, and I am getting the best sound from this.
However there are some major caveats to that result, and the biggest one is that my current DAC does not draw 5v from USB and is not affected by USB power conditions, and it has a good XMOS setup. With those DACs I did try that do draw power pretty much anything can happen to affect the sound. So much so I would advise buyers to avoid units that have poorly designed USB interfaces and to challenge manufacturers to not cheap out and use the +5v from USB.
To get to the point here I feel the Wyrd is pretty interesting and may help out some DACs but the hope is that the reference USB designs everyone uses can be improved.