Most tubes will be good for around 2500 hours if they are new when you get them....there are 10,000 hour tubes also.
The EL3N tube amp that I have , those tubes are 10,000 hour tubes.
Of course they may not last that long, as any tube could go bad at any time, but quite honestly, they last a long time.
When a tube goes bad it could go silent in one channel of the amp, or it could get unreasonably noisy...or make weird sounds.
I have always used tubes and in all of the time I have probably had less than 10 tubes go bad...i have pitched a few because of noise, though.
The tubes in the top amp are 10,000 hour tubes...the tubes with the red bottoms. Tubes are far more dependable than people give them credit for