My take on the RS120 vs RS180 vs RS220 is that at least the version of 120 I bought five years ago, was considerably worse in both range and sound quality than the 180, and that the difference was much bigger than between 180 and 220. I used the 120's for three years, but can't remember much else than the constant annoyance of the static in the background and that after two years they were falling apart. Once I got the 180's, I ditched them almost immediately. If Sennheiser hasn't made any significant changes to them, I'd definately pony up for at least the RS160 that can be had for just under 200$ and should basically have a similar sound to 180's.
180 vs 220 is more difficult one, especially considering the shortcomings of DSSS vs Kleer, but soundwise I'd say the biggest difference is the soundstage and separation 220 provides and how much better it makes the listening experience, especially with music. 180 just hits you with all the sound in one big lump, whereas 220 spreads it over a bigger area and layers it to so that you can either conciously concentrate on one aspect of the sound or just let it wash over you and immerse into it. 180 might even very well have the same extension of highs and lows, but it's much harder to tell them apart from the mass of sound, and it can also be quite tiring on some music that already has the same "in your face" -representation in the recording. Other that that [IMHO huge] omission, they have a pretty similar sound, in that both are generally very easy to listen and even completely tune out of the music if you need to concentrate on something else, and also forgiving to poor sources. There are no offending highs, booming bass or sibilance unless it is extremely accentuated in the recording. In movies or tv use there isn't that much difference, but the 220's soundstage has fooled me a couple of times to think that it's my phone that's ringing or that a siren is blaring outside my house instead of the program I'm watching, whereas the 180 hasn't done that in two years. Speech intelligibility is also pretty similar.
But again, take my impressions with a grain of salt, since RS180 is pretty much the only yardstick I have, I can't comment on how big the difference actually is or if something wired would be leagues ahead of them both. I have recently bought Sony MDR-EX600 iem's, so I might later try to give some kind of comparison to them, as much as it is possible or viable with different type of headphones.