The DT880 is too bright for me, that's why I never purchased it, so why does anyone stick with it? And it's sound is enclosed, typical closed-back, but the HD600 we all know is spacious without sounding hyped.
And also many people buy the Audio Technica ATH-M50 on advice from a friend or their headphone stockist, and they suppose they have the end-game headphone, I feel sorry for them, maybe their headphone dealer should stop giving them negligent advice and just point them straight to the HD600, it fits within the category of end-game headphone for me.
The DT880 is a bit bright, but it has some pretty good things going for it. It has excellent extension on both ends; as wahsmoh points out above, it definitely goes deeper than the HD 600, and though it's a bit early for me to tell, I think it goes a bit higher as well. It has a bit more air and presence and a less forward midrange than the HD 600, which, depending on preference, might make it work better. Some people actually find the upper mids (~3 kHz) on the HD 600 a bit fatiguing because of the slight lift in the response in this area. I personally don't have much of a problem with it, but this region is definitely the volume limiter for me, whereas on the DT880 it's the treble.
I like them both. Swapping back to the DT880 after having listened almost exclusively to the HD 600 for a few days, there wasn't quite as much difference between the two as I had initially thought. Mainly it was a difference in presentation, with the HD 600 feeling more intimate and in your face, with the DT880 feeling a bit more relaxed (apart from the mid treble) and further away. I still prefer the HD 600, but I'm happy to have both. The way the DT880 presents orchestral strings, for instance, doesn't quite match up with what I heard in a live performance, but I still like the presentation a lot. And for organ and (oddly enough) EDM, I still prefer the DT880 on account of its deeper bass extension.
And the M50? It was my first decent headphone, sometime back in the Cretaceous Period, and while I could see the appeal at the time, ultimately the signature just didn't work for me. The upper midrange is just too laid back for my taste, and the bass is too heavy. I found myself staring, unmoved, at the wall instead of enjoying the music, and it was at that point I knew I had to get shot of the thing.