ASIO bypasses windows audio bs, so no resampling. ASIO just plays the native track of whatever is being fed to it. So even if my windows settings is set to 16/44.1, if I play a 24/96 track in say foobar2000... the Mini-i Pro bypasses the 16/44.1 and plays the 24/96 track at 24/96 without you having to switch any settings. I find it very convenient at the minimum.
As for your usage, I'd just use Pre2 for the Mini-i Pro's volume control of the line out to your active monitors. It's easy to swap to Pre1 if you want to swap to headphones or DAC if you want to swap to an external headphone amplifier. All you have to do to swap settings is hold the volume knob pressed in while turning it off, then while still holding the volume knob pressed in turn it back on. The settings menu is displayed.
The Mini-i Pro also has the benefit of a remote control if you aren't beside the unit itself. I never need to use it, but again, I can't complain about having it if I ever need it.