One thing that I notice is that I nearly always have to release the air pressure built upon inserting these into my ears. If I insert them without doing so, the mids and bass become muted and it ends up sounding more distant.
I do this by gently lifting them in one direction (in my case, lifting upwards works best) while they're inserted, which breaks the seal temporarily, releases some air, then upon letting go it re-seals and brings back the full sound. It makes me wonder how many people are affected by this as much as I am and aren't hearing the full potential of these IEMs.
This is with Auvio tips, by the way. It may be that these tips make this issue more prominent for me, but these tips are what makes the RE-400 sound the best to my ears.