I've tried to catch up with the thread... Some things to add:
1) You don't have to use specifically Beyer pads's fillings in order to mitigate that slight edginess in treble... Similar materials used for modding the HD800 are good enough (felt or rug pad or similar). Felt is going to make HE-4 very slightly warmer (still a good portion of air and quite nice imaging, just a little bit warmer signature with more impactful sub bass) while rug pad is not gonna change them at all (only very slightly decrease the edginess). Try to do that instead of changing pads from stock... Not worth it unless you really want to alter their FR.
2) I would really call the HE-4 a perfect downgrade headphone from the HD800... I was always thinking about HE-500 but once I found HE-4, I knew these are perfect for me. Better than DT880, K712 Pro, HE-400, HE-500 etc. HE-4 are like a perfect fusion of Hifiman's timbre+ortho bass and HD800's airiness, soundstage, speed and detail. Mids are not recessed subjectively - rather accurate, not lush but not recessed. They are not perfect (imaging is not HD800's like, there is some increased level of distortion in lower treble)... But for anything up to price of HE-500, they are a steal. The best value-for-money headphone I have experienced so far... And I agree that I would seriously hesitate to buy HD800 again now that I have the HE-4.
3) The treble of HE-4 is different from the one of DT880... And bass is different as well. Timbre is also way too different to even compare those two and call them more or less the same. HE-4 are significantly better. I mean - I prefer HE-4 even to LCD-2 rev2 while DT880 are definitely not on the level of HE-500 or LCD-2.
4) They are not so hard to drive... They have single-ended drivers and comes with a 3.5mm short cable for portable usage. Yes, I would not use them with my smartphone but I tried to plug them once and listen to a song or two - and they sounded good that way. Harsher, with rather badly defined soundstage but bass was still tight and the overall sound completely listenable. Of course, my Yulong DA8 (in both balanced and unbalanced mode) gives better results but I would never call HE-4 a very-hard-to-drive headphone. I've tried many headphones and yet the bass is one of the best I've ever heard and they do not sound harsh at all from the Yulong so I don't think I am underpowering them at all.