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There's a certain natural soundstage (read: realism) that comes with an out of head sonic experience, custom IEMs sacrifice this. Even full-size headphones don't escape this (except MDR-R10s). For that kind of experience, it's speakers > MDR-R10s > full-size headphones > IEMs.
I'd agree with this. As impressive as the soundstage of my customs (JH16 and ES5) can be--and a balanced cable and SR71b amp make it even wider and airier--I have found that the soundstage of customs just can't match the holographic nature of the best full-size cans. The LCD-2's soundstage may not be on the level of the HD800's, but it can definitely portray an out-of-head, inches in front of the face kind of image. My customs can play cool tricks within and directly around my temple area, and I never feel like the sound is congested or claustrophobic, but the space for customs to play in seems basically limited to within my head.
Aside from soundstage, I think customs can definitely compete with, if not surpass, the technical ability of the best full-size headphones I've heard. Within the more limited soundstage canvass that the ES5 and JH16 have available, they both have amazingly precise imaging. And the tonal balance, clarity, and detail retrieval of the ES5 and JH16 are at least as good for me as the LCD-2--with my meager equipment. But really, that's another advantage of customs: They can sound near their best on portable, reasonably-priced sources and amps. If anything, I would think that they won't sound good on the top-tier desktop amps, unless the hissing can be controlled and the channels can be balanced at comfortably low volumes.
It comes down to how much you are willing to spend, and what settings most of your listening will take place in. If I did most of my listening at home, and had the money and space for a full desktop rig, I would definitely choose a full-size headphone system over a custom IEM, mostly for the expansive soundstage and more comfortable long-term listening of an over-the-ear headphone. But customs allow me to have sublime, if somewhat intimate, musical experiences wherever I go...