I also got my RS220's last week ( thanks again for the lookat.co.uk tip mcnoiserdc, you saved me more than 100€) and have probably about 100 hours listening time
First of all, the sound is awesome. Granted, my previous experience is mostly from the previous Sennheiser wireless flagship RS180 (several thousands of hours), Superlux 662f (couple of hundred hours) and several under 50€ iems, but I still think this is something quite special. Also the fit is, at least for me, pretty much perfect. Same goes for the physical build quality.
However there are some chinks in its armor, or at least things RS180 did and better. First of all, battery life is considerably worse with the RS220, I probably get around 8 solid hours of listening from them, whereas the RS180's would go on for 18-20 straight hours with similar 1000mAh batteries. This isn't such a big deal, it takes 15 seconds to swap new batteries, and at least the battery compartments are more easily accessable and durable than the RS180.
Another thing where RS180 takes the cake, is range. With RS180 there are only two places in my apartment where the connection would break; a metal-lined walk-in freezer and tiled shower corner, both with three insulated walls and 5 meter distance between transmitter and phones. RS220, however, starts dropping sound when there's just two walls between the transmitter and phones. I don't know what the difference in range is in free air outside, and since it's -30C outside, I'm not willing to go and test. I also prefer the way RS180 just drops the signal and resumes when it's back in range, the choppy cutting 220 does can be a bit annoying when you're hovering on the edge of the range. Again, not such a big deal, but just something I noticed.
Third thing is the humming/whining noise otinkyad noticed, I can also hear it, and at first it was so noticeable that I even considered returning the phones, but either I've grown accustomed to it or it has subsided quite significantly. I'm pretty sure this is something that comes with the technology, since a similar noise is present in the two pairs of RS180's I own, and I've tested them in environments with no wireless signals or other disturbances, and I even tested the RS220 with battery power to see if it is the noise from the switching psu it comes with, but the noise is still there to be heard the moment the dock connects to the phones. At first this seemed like a dealbreaker to me, but as I said it seems to have subsided and is now at the same level as it is on the RS180, meaning it must be completely silent (basically at night), nothing playing on the phones, and I have to cup the headphones with my hands and really concentrate to be able to hear it. Now I should also state that my hearing has been measured to be fully intact and I'm 25 years old and I'm really sensitive to noise (can't have analog clocks in my bedroom because of the ticking etc.) and I have to really strain myself to hear it, so I don't think this is really a big problem, but I am still interested in hearing if otinkyad gets some info on this or another pair of earphones to test.
Okay, after these ramblings I can only say that despite their weaknesses I absolutely love the RS220's and have hardly used other headphones since getting them, especially listening to music is just so much more enjoyable than with the 180's, that I've stayed awake through couple of nights just wading through Spotify listening to my favorite tunes and even some totally new genres of music just to see how they sound with these. So I'm a very happy camper right now.