I've had these headphones for about 5 years now. I use them in work, currently hooked up to an O2/ODac, previously a hifimediy sabre usb dac. They are pretty easy to drive, the O2 is definitely overkill (1x gain, between 9 and 11 o'clock).
They are comfortable enough to wear for 8 hours a day if required. Clamp force is light, pads are big enough and soft enough.
For a long while I thought their sound was a bit boring. Couldn't quite but my finger on why. Lacking a bit of bass impact, not enough sparkle in the highs. In hindsight I was seeking a more coloured sound, later I was seeking detail retrieval (veil removal?).
However, the more I have auditioned replacements for them, the more I have come to appreciate them.
I've had and returned or sold:
1. MSR7s (trebles fatiguing to me - otherwise great - comfort, build, exciting sound).
2. Shure SRH840s - Only a brief audition, but they didn't feel like an upgrade to the 6400s. Possibly should have held on to these longer, initial impression was that they didn't do anything the KRKs couldn't.
3. NAD Viso HP50 - Great sound, balanced and articulate, but uncomfortable - the headband just created a sore spot in the middle top of my head. The pads and clamp force were just about acceptable.
4. PSB M4U 1 - Similar sound to NADs although I preferred the NADs, but even worse comfort than the NADs. Clamp too tight, pads not deep enough/crush too much - sore ear lobes.
5. Brainwavz HM5 - I initially though these were broken, because they seemed to have no bass. Tracks would literally be missing part of the frequency. Otherwise, they were really comfortable. But the sound was way too lean, distant even.
6. Ath-M50s - not as comfortable, but acceptable comfort wise. The bass exaggeration is initially interesting, but ultimately distracting. I would probably take these over many of the above (MSR7, NAD, PSB, HM5) almost by default. They are not disqualified by discomfort, fatiguing or otherwise unacceptable sound.
So a bunch of well-rated headphones that in one way or another are incompatible with my head/ears.
Meanwhile the 6400s roll on. I've been appreciating their transparency and versatility.
So I welcome any other suggestions, but I feel I'm going to be sticking with them for another few years.