Not true, thicker can be less flexible, in which case the subjective desire for ergonomics could win over any tiny difference in resistance and capacitance. But then there's strand count...
So let's just wait and listen to someone who had tried both, or avoid commenting.
My Hifiman HE400's original cable was a Canare coaxial (the type that got 3 polarities all encased in 1 jacket). My DIY cable is 1 polarity/cable, so I ended up with 4 cables, braided. I'm not familiar with AWG measurement, so I'll just show it in this picture:
As far as audible differences, I can't hear any. It's heavier, that's the sure thing. Flexibility, I'd say more or less the same, as the original cable was quite stiff anyway. The main reason for using this cable is purely aesthetic, for me.