Here's the real deal:
All Mid-range Grados have a very similar and peculiar house sound colouration since they share similar / identical drivers. And that colouration is basically peaky treble, very smooth and flat mids except an upper treble peak (causes the "shouty" feel of Grado sound), and a slight mid-bass hump followed by a huge and quick bass roll-off.
A few examples:
http://www.innerfidelity.com/images/GradoSR225i.pdf
http://www.innerfidelity.com/images/GradoSR325i.pdf
http://www.innerfidelity.com/images/GradoRS2.pdf
With the repeating treble pattern you see here between different Grado lines, in particular, lots of people find it way too peaky for their tastes. Others like treble-heads and those who seek ultra-EQed-up treble details find it exciting.
If you tolerate or perhaps even thrive with peaky treble, and don't mind a bass response that is punchy (midbass hump) but lacks body (zero lower / subbass), and ultimately want an extremely smooth but slightly shouty (upper mids peak) mids, the midrange Grados are perfect for you, any difference between the different Grados would just be very very minute treble signature differences.