I am not expert in audiophile vocabulary and English is not my native language, but for me 'sterile' and 'clean' are not the same or at least it shouldn't be, IHMO. "Clean" means free from distortions, both harmonic and non-linear like jitter or other intermodulation effects on non-linearities of the components.
If you ever heard high-end setup (not in a shop, but a continously improved gear during many years), you know what I mean. R2R11 has surprisingly all attributes of high-end sound except being clean. It is not totally bad, as we are able to tolerate some kind of distortions. I have awareness it could be better (same as the OP). Some other member says: R2R11 is a "gateway to the high-end sound". I do agree, it create desire for something better, but sound imperfections don't throw me away. I can listen to R2R11 for hours without being tired, the same as to the local FM station that use high-end DAC.
Sterile sound is created both by some Delta-Sigma DACs with extensive DSP and a currently popular amplifiers with nested-loopback. Examples are THX 789, my FiiO E12A or the latest Topping amps. These are also examples of clean sound, but not similar to the high-end equipment, as something is missing. This is why I call it 'sterile'. You may have an impression of a high resolution, but it is misleading, as in a case of DS DACs harmonics are fake, sound is simplified (various tones of a single piano key are blended into a single dominant tone or it sounds distorted), also missing natural reverbations on a decay. Nested loopback amplifiers are losing transparency during fast transients (which is music). People call it sounding 'dark', uninvolving. 798-types are popular when paired with DS converters, as sound is simplified already.
I may agree about Ares in this aspect. In the Ares there is no pure NOS mode. Data streem is subject to DSP pre-processing even in NOS mode, it cannot be switched off. It may sound more sterile for this reason. It is why Audio GD R1 is a natural upgrade for R2R11.
There are many ways to clean sound of R2R11. A ladder is sensitive to ground loops. It helps reversing plug on the laptop PSU (possible with 2-prong Europlug), blocking 5V pin and attaching two ferrite clamps on both sides of the USB cable. I plan to make my own USB cable. There is a current discussion in the DI-20 section for chosing the best USB cable. If it helps DI-20 that has galvanically isolated USB port, it will make even greater effect on R2R11.