Better to do it in one place. Either disable headroom or adjust the gain (using the slider on the right). I like leaving the headroom on as I get the clipping indicator. But do remember that you loose quite a bit of headroom when applying large changes, I prefer to keep things below 6dB when it comes to the maximum change I am willing to apply, your amp will have to work a bit harder so you lose some dynamic range.
Since many seem to be using
@Resolve's EQ, I wanted to leave this here so you know what the EQ is doing and you can adjust the right ranges if you feel it is a bit too much. Personally I feel the treble is too forward (clearly heard when playing pink noise) and the bass sometimes gets a little overwhelming with this EQ for me, but I understand it is personal taste so use responsibly