You will be hearing the amp very close to it's best with this combo IMO. I don't own the 421A, but the 5998 is among my couple of favorites and the ECC32 are the same.
I don't listen to 6BX7/6BL7 these days, but they are also very good as power tubes.
I am listening to GEC 6080 and ECC32 and it is also a heavenly sound...to be honest the ECC32 pairs well with all of my power tubes and it definitely deserves the accolades that it gets.
You may pair it with different power tubes depending on music you are listening to and headphones you are using.
I find the ECC35 the most picky of the ECC3X drivers, due to it's higher gain.
The best thing is that the amp will sound very good , even with the cheapest of tubes.
With the great selection of tubes that you own, you are in for a wonderful time and some sublime listening sessions.....enjoy.