I just visited a local audio shop and auditioned the O2 and the D-Zero. There are few other amps from Alo and Ibasso but I don't have much time. I spent almost 30 minutes with the O2 trying to compare it with the DX50's amp. I can't really make a clear difference in SQ except obviously the O2 packs more power.
Compared to D-Zero, my initial impression is it's a step back a little compared to DX50. D-Zero sounded a bit compressed than DX50.
I used my JH16, so I think the comparison with O2 is moot since it does not need much power to drive it to it's full potential. Perhaps a full-size headphone or a hard to drive IEM will show a clear difference.