Just wanted to give my thumbs up for these cans. I've had them on my head for 6-7 hours a day every day this week at work with a V-moda Boompro attached for VOIP calls. These are just excellent cans comfort and sound wise. Love the lushness, mid-bass kick and sparkle. Isolation is plenty with music playing but I can still hear myself talk while on the phone which is great. When a pair of cans is so closed up or noise cancelling that my own voice is extremely muffled it's harder to talk IMO. The semi-open design is also great for alleviating the pressure on your ear drums that can develop after long sealed sessions.
My home set is a pair of AKG K7XX and comparatively, they have less mid-bass, more sub-bass, more air and a wider sound stage, a fairly equivalent mid-range and a bit more sparkle up top. They are also extremely open which wouldn't work for the office, and need a lot more power to drive well. I also own Beyer DT990, ATH M50s, ATH MSR7, and if I had to keep just one pair it would be these L2s for their versatility, comfort, and SQ.