I've been considering, lately, re-trying the optical out approach. You are limited to 96 kHz (not that it matters, but that's for another thread...) although I read that the newer generations of MacBook Retinas will actually do 192 kHz from that port. And, of course, you need a mini-TOSLINK adapter. But, prior to the whole async USB hysteria, I thought optical out from a Mac sounded cleaner and with no pops/noise.
Continuing on...
While I have experienced drop-outs with the DAC side of things, I have been able to place drives on the busy ports with fewer problems. On my MacBook Retina, I am using a USB-powered 3.0 drive which will read/write 80+ MBps (plenty fast for music, especially with 16 GB of RAM to cache). On the older Mac Mini, I placed a Seagate Hybrid drive (1 TB 2.5" HDD with 4GB NAND Flash) into an aftermarket enclosure. Even with USB 2.0 it's performed nicely (roughly 37+ MBps), due to very aggressive caching which also mediates latency issues.
I've made heavy use of Firewire in the past, which is faster than USB 2.0 and avoids the bus conflict issue, but reliability depends on the devices. With Seagate HDDs I've been able to daisy-chain devices, but with my Drobo I've had connection issues since Mountain Lion.
Thunderbolt... yeah... who buys those?