After almost 50 hours of burn-in, I started listening to the C421 w/AD8620, which sounds really good. One thing that that really strikes me is how similar it sounds to my Ibasso D7--maybe a little wider soundstage with the C421 on some recordings (not deeper, but wider) but extremely similar in tonality and SQ. The funny thing is, previously I was looking at this as an alternative to the built-in amp on the D7, which I thought was a tad too warm for me after 100+ hours of use. But since then, it seems like the D7 has actually become less warm even after the 100 hours (it has a lot of caps). When I first got the D7, it seemed just as warm as my Fiio E10, but now it seems a bit brighter than the E10.
I'm now liking the D7/DT880 combo more and more, prior to even hearing the C421. Now that I have it, I plug the C421 into the line-out of the D7 and switch back-and-forth between the D7 DAC/D7 Built-in amp combo vs. the D7 DAC/C421 amp combo, and am surprised by how similar they sound in tonality and SQ--at least with only around 50 hours of burn-in on the C421. According to posts in other threads, Ibasso support said that the D7 uses the OPA1611. I don't have any great cable connecting the devices, though, and am just using a stock cable that came with another amp, so that could limit things.
Doing the same A/B testing (using the same cable) with the Fiio E10, I definitely notice an uptick in SQ with the C421 as amp vs. the E10's built-in amp--but it's harder to detect a difference with the D7. Although I do also like the combo of the E10 as DAC-only with the C421 as amp. I've only used the C421 on its own (no DAC) for a little bit, but it sounds great by itself using an LOD into an iPhone 4S as well as a basic 3.5mm cable into an Amazon Kindle, listening to some "-q9" Vorbis files. Very clear and defined on both devices without any over-the-top brightness or obvious sibilance.
In terms of phones--since they sound very similar to me, I'm liking the C421/DT880 combo every bit as much as the D7/DT880 combo. The AD8620 suits the slightly-warm DT880's extremely well. What I didn't expect is that the AD8620 works fairly well with the K702's--although admittedly, I haven't tested them nearly as much as the DT880's, only listening to one album with the K702's. Keep in mind that I only use my K702's when listening to 100% acoustic instruments, so I can't vouch for anything else. In any case, I had expected the combo to be too harsh, but haven't found the K702's to be harsh so far. Maybe because of all the prior talk of "brightness", it skewed my expectations…but I don't find the AD8620 to be extremely bright--I find it to be pretty neutral and defined.
Also, there's more than enough power to drive the K702's, DT880's, and DT990's, although I've only tried the DT990's with one song, so I can only speak on power for those right now, not SQ. In any case, like others here, I'll continue playing around with things…