Short answer, yes.
The RS2e are much smoother and simply much clearer than the SR325is. The 325is lack bass. Headphones without bass are useless. I find the 325is too harsh to listen through! Funny, I've tried the SR325e and found them much improved? The 2e just are way more accurate and enjoyable. They're much lighter and look much better.
It took me a year to except the price jump, however I have no regrets. They are my reference cans of seven..that includes a pair of vintage Stay. But wait, when purchasing the RS2e I also listen to their limited run GH-1. They took the RS2e and tweaked the low bass and it was delightful! I just couldn't in all honesty see another price jump for a another octave of punchy bass?
I went back and force and I am happy with my choice. I hope that helps?