I had a V280 when I first purchased my E2 I thought the pairing was very good.
Really, the only deficiency I've heard from E2 out of any chain is the lack of dynamics which I heard when E2 was driven from my Liquid Platinum with some of the Amperex tubes I tried with it (and from my Cowon Plenue II mk2). But in general, I haven't felt like E2 was particularly 'amp-sensitive' (the way my Auteur are for example). Actually, I might call them the 'least amp-sensitive' of all my cans, as long as there's enough power and current to drive them. V281 will certainly provide that.
I guess the only possible concern might be that bit of warmth from the V281 pushing the E2's sig in a direction you don't prefer, although I imagine a small amount of EQ could make that problem go away (all wild-ass speculation).