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USB power is pretty noisy and I can easily see it being different from port to port even on the same computer
And not just the power... The data signal transmitted from a USB port consists of a waveform that the circuitry on the other end is going to try and interpret as a series of ones and zeroes. If the signal is "clean" then that process should be quite unambiguous. But if the data signal itself is "dirty" or "noisy", then you can imagine how that introduces complications into the process. Ignoring for the moment what the the sonic consequences of any such "noise" might be, or just how much "noise" in the data signal is necessary for its consequences to be audible, there exists sophisticated equipment that electrical engineers can use to observe and quantify this "noise".
Although I have not seen it myself, a friend with substantial credentials in the industry (he designs DACs, not cables!), who has done such measurements, has confirmed to me that there are some very significant differences between computers, and even in some cases between individual USB ports on one computer. FWIW, he mentioned to me the Macs generally have very good, clean, USB ports. I happen to use a MacBook Pro, which he tells me is very good, so I'm happy
. Also, FWIW, he tells me that most "Audiophile" USB cables do not appear to offer any measurable differences over standard cheap data cable,although there are a small number that do.
My own experience - which was very much contrary to my expectations - was that a Nordost USB cable totally blew away a (relatively) high quality data cable, to the extent that I questioned whether the demonstrator was pulling the wool over my eyes. But I bought the cable, and can easily replicate the results on my system at home. Make of that what you will...