I'll try, difficult to find the right words!
One thing that stands out to me with the RU6 and did also with the R01 is the way the whole mid-lower section is presented. It's not that the frequency range is necessarily emphasized, but it feels fuller - almost as if something about the way the dynamics and decoding of the R2R pushes out the sound is different. Of course that may sound crazy, as a sound wave is a sound wave, but they feel like they're pushing more air across the whole bass-mids, or there's more present in that part of the frequency spectrum than a typical delta-sigma DAC. In comparison, the Chronos sounds 'cleaner' or 'tidier' in its presentation in the bass and lower mids, as there's less fulling out the sound in those ranges - as if the instruments that are quieter in the mix are further down, allowing the more forward elements of the bass/mids to stand out more against a quieter backdrop, whereas with the R2R presentation instruments in the mids and lower, like guitars that are still ringing out, are further forward so that in general the R2R sound seems fuller. But one of the things I love about the Chronos is it has a very natural presentation of the upper mids and treble, so both actually come off with a lifelike timbre and natural sound, just in different ways.
In all honesty I'll probably keep both - the Chronos is great, has lower power draw and is a bit smaller for on the go use. RU6 - also great, in a slightly different way. Keep in mind I've still got plenty of burn to do on the RU6; if anything I suspect it will just get better.