That is basically how I use my NFB1. I have the Breeze DAC feeding the NFB1 and then from there I pre-out to my Woo WA3 tube amp for when I feel like tubes. It works really well. I have no doubt feeding powered monitors would work excellent. You can set the monitors at a relatively high level or where it performs at best and then use the NFB1/R28 volume knob that is based on digital control relays and is probably better for sound quality over the full range.