Funny - with the original NFB-12 my understanding is complete opposite. I noticed no difference in sound-stage between optical and USB, but there is apparently some treble roll-off with USB (there was a thread here quite a few months ago where it was discussed and even measured). Can't say I notice any difference either way - I compared the two a lot when I first got the unit, and couldn't tell the difference.
I think that's why Audio-gd worked on the NFB-15 (essentially an NFB-12 with upgraded USB).
Go with what you prefer (some people prefer rolled off treble) - but my preference definitely optical in this case - simply because I can then use DSPs from my X-Fi if I'm gaming.