Didn't want to chime in until now since I'm not familiar with U4S and only heard IE600 for the first time at CanJam NYC '23. To support what you are saying, you can see how these two IEMs compare in FR below. In terms of bass quantity, you can get closer using M20 apex (more isolation, more bass). But treble is noticeably elevated in IE600, could be too much energy for some. Also, the seal issue w/IE600 is due to a tiny shell and a stiffer cable, a bad combination
Btw, U4-SE (limited special-edition) brings back some good memories when I reviewed it in 2017, still have it