The simple answer is that the RU6 DAC doesn't have the drivers to do this. All of the Audio Interfaces use software loaded on a the interface to accomplish this. As I said before USB isn't an audio interface it is a data transfer interface. Much different.
Anyway, I found out that Roku boxes have squeezebox support. Roon supports squeezebox and can transfer over ethernet. Do you have an ethernet port on your Roku?
If you don't have an ethernet port, you could get a HAT on your pi that has SPDIF input and then transfer that to Roon and setup your RU6 on another of the USB ports on your pi with a usb-c to USB-A cable and there you go. No expensive audio interface. I don't think you would even need to go to squeezebox to do it this way.
I see that the MainSqueeze channel (app) on Roku can stream music to my Roku --- but what I want to do is watch TV (on various Roku channels - Philo, Acorn TV, BritBox, Amazon Prime, YouTube, etc.), and have the audio (which comes out on the HDMI port) somehow be connected to the input of my Cayin RU6 USB DAC. Right now, I have a HDMI->SPDIF (optical) adapter, which is connected to my 4x4 Optical Matrix Switch, and then to several DACs with SPDIF inputs.
This whole series of posts, is due to my desire to be able to connect DACs that only have a USB input, to the various non-PC audio sources in my system.
I know that before RaspyFi became Volumio, a web page [
http://www.raspyfi.com/the-right-usb-dac-for-your-raspberry-pi/ ] was created, that lists various USB DACs that could be connected to the Pi, for listening to audio.
The only reason I've mentioned Roon, is because I've seen it mentioned that some people use a Pi as a Roon Endpoint Music Player, with an external USB DAC connected.
I use JRiver Media Center (on Win10 & Linux) to manage my music files, and don't have any interest in buying, or setting up, Roon for myself.