I've heard that the O2, while transparent and decently powerful, doesn't add anything to the music and leaves you wanting a bit. My Lyr makes my HD600s shine. I'm currently listening to Money by Pink Floyd -- I can't really say it sounds anything other than awesome. I'm not a huge Pink Floyd fan, and I know this is one of the most popular songs, but it just sounds fantastic.
If you like choral music, Eric Whitacre is an American composer who writes some amazing contemporary pieces. I've heard a few live (sadly not directed by him) but my sister sang at Carnegie Hall in NYC as part of a large choir directed by him. He loves dissonance. They are absolutely chilling with the HD600s and the Lyr.