I used the M6 for several days after purchase and there was a harshness to the treble that made them almost painful to listen to, and the bass was a bit loose. That was the first time I tried burning in IEMs. I expected nothing. 20 hours of pink noise later and it was night and day. Harshness faded drastically, bass tightened.. I know the brain will adjust in order mitigate/correct sensory input (which is why it's good to give them time), but that sort of acclimation is generally gradual. The burn-in change was acute. Also I could be nuts. Anyhoo, they can still be a bit aggressive for me at times, but as others have pointed out, they have a particular talent for techno. (I do wish the bass had a bit more impact, though)
I cross-train in them and they are exceptional for activity. They aren't going anywhere; in fact taking them out is a bit of a hassle. When someone's talking to you, you can't just pop one out for a couple seconds and put it back in like a barrel IEM; it's a minor production.