I haven't encountered any noise from mouse or high load while gaming (4790k @ 4.7ghz 1.3v, GTX 980Ti - yeah old) prior to connecting the Jitterbug so I cannot say if it resolved any noise issues if I havent heard any to begin with. My USB output with the Jitterbug remains the same, I can still send DSD files (2.8M) to the HD-DAC 1 with no issues. I suspect it is your software that is having issues. I use Foobar with DSD plugin. I'd liek to comment though that through Optical, I was able to hear noise via sensitive IEM and the amp gain @ high and the knob @ 2o'clock. When I switched back to USB, it became silent again. Possibly because my optical comes from directly to the PC's noisy motherboard. I suspect if I use a standalone usb to optical converter it will yield better results - but there's no need because the USB input from Marantz is quite good.