I have some initial impressions after a few days with the he-400i. Keep in mind that this is my first open eared headphone.
The first thing I notice is that the bass, while tight and accurate, is not very prominent. I'm not using the best amplification yet, so I'm not sure if the bass impact and quantity would increase with a better amp. Compared to my RHA MHA750 IEMs and AT-M50x the bass presence is noticeably less in quantity and slam. I'm actually hearing it roll off quite a bit in volume below maybe 80 hz. Personally this takes a bit of 'fun' out of the headphone.
Lower mids to upper mids are more forward and elevated in the sound signature. I'm liking the amount of detail here for things like acoustic guitar and vocals.
The treble has a good amount of sparkle. Maybe more than I'm accustomed to coming from warmer, smoother IEMs. It only really gets sibilant at higher volumes for me, though my ears are rather sensitive to high frequencies.
I can't speak to much about soundstage and imaging at this point, but I will note that this headphone separates instruments better than any headphone I currently own.
Overall, I'm liking these headphones. They sound detailed and are very comfortable. Listening to something like Daft Punk's Random Access Memories (24/96 HD Tracks) leaves a little to be desired. I'm picking up all the little details, but my home speaker setup (Monitor Audio Silver s10) and IEMs (RHA MA750) are a little more satisfying thanks to the fuller bass down low.