Well right now its hard to say as I don't currently have a decent or well matched amp for the HE400i. I normally listen to my HD650 straight out of an Asus Essence ST sound card, which sound great together, but the same can't be said for HE400i. It's like sound is compressed and lacking body. Not completely unlistenable, but not really good either. They are also quieter than my HD650 out of the Essence, which makes no sense since they have a 35ohm impedance compared to the 300ohms the HD650 has. The Essence ST can make the HE400i plenty loud, but it just does not sound right. They also sound too quiet and weak out of any portable that I've tried, despite Hifiman advertising them as being portable friendly.
In any case, after much faffing about, I actually found them to sound best straight out of my Chromecast Audio which just makes everything even more confusing. For the time being I will continue using them out of the CC Audio. I have ordered a Schiit Magni/Modi 2 Uber stack which I'm still waiting to be delivered. Hope they are a good match otherwise I will be well annoyed!
In any case, have been running them for a few hours now and quite certain that they are sounding a lot better than when I first tried them. The mids seem more forward and the bass has more impact and body. Actually they sound pretty damn good out of the CC Audio and already I can tell that they have more high end detail and separation than the HD650. With regards to the sibliance issue, it's only seems to be sibliant in certain songs, primarily poorly mastered tracks. On the good tracks, it's not sibliant, just piercingly bright. I'm guessing this is just me not being used to bright treble as I've been using the HD650 for the past 5 years.
Would also like to mention that I find it pretty lame that Hifiman couldn't bundle a longer cable. The one they provide is hilariously short. Plus, a right angled 3.5mm plug on such a massive headphone? Really?
None of my phones or tablets can even run them adequately! Not sure what they were thinking there. Rather than spend that money on that pretty but ultimately useless carrying case, they should have bundled a longer cable with 2.5mm plugs (thanks for the correction
fjrabon) that don't look like cheap plasticky pieces of crap.
Other than those things, I'm reasonably happy with them thus far. Comfort was an issue at first but slowly getting used to them now. Just hope the mids come more forward and treble settles down a bit. Hoping the Schiit amp/dac will make a difference; it's the most I was prepared to spend on this setup.