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I am still suggesting those who find RE0 too thin for their taste to get a pair of Comply TX400. IMO, you haven't really heard everything about RE0 before you try the TX400.
Tips make that much of a difference? Is it because the RE0 is able sit deeper in the ear?
No, not because it sits deeper in the ear canal, but everything to do with altering the acoustic impedance of the IEM. Many hate Comply because they think it muddy up the sound. More precisely, it (as all foam tips do) increases the acoustic impedance of the IEM and shifts more energy from transient to decay and harmonics which allows the body of a note to build up more easily. Of course the reason why people hate it is mainly on the fact that it slows the leading edge down and therefore each note is getting less defined (= muddy up). But on a relatively fast and lean IEM, the increase on acoustic impedance actually provides a positive effect. A few good examples I have experienced with will be RE0 with TX400, Phiaton PS210 with T400 and Etymotic ER4 / MC5 with Shure olive. In the case of RE0, the effect is especially noticeable with the TX400 because TX series has a build in filter that add more acoustic impedance to the mix but doesn't take away too much of RE0's strength in speed. They are rather in good balanced IMO. It is kind of similar to how Phonak does to the PFE with different filters (grey filter has less rated acoustic impedance than black filter, and black filter has less rated acoustic impedance than the Perfect Bass green filter). By increasing the acoustic impedance, you smooth out more and more of the treble and allows the bass to build up. It is a trade off no doubt, but getting the right balance to fit a person's taste is what important here.