I'm sure people who buy a Blu2 and who own a DAVE will test your theory out by applying their favorite isolation techniques and draw their conclusions. I have thought about this also which is why I posed the question to Rob.
Rob's response was that as long as you have galvanic isolation before you hit the analog stage, you will be fine and as I look back at my own experiences, I would have to agree.
People on other forums talk about the significant impact of network isolation transformers, optical FMCs, leakage current produced by the PSUs that power the music server, Intona, etc., and I have to say that I have gone through all of these things and they have had a minimal impact at best, certainly nothing so great where I have felt them to be necessary or of high value and so I have removed all such devices from my setup. I believe that is how good DAVE's galvanic isolation is on USB.
With Blu Mk2, galvanic isolation will still occur before the signal hits DAVE in the same way as DAVE's USB input. The benefit of having galvanic isolation at the DX outputs is that it benefits all the inputs including CD playback. It further strips away RF introduced by M-scaler's 10A switching PSU. And so with Blu Mk2, as I have thought about it, the only benefit USB will probably have over the SPDIF input will be convenience and a more simplified chain for those of us who don't want to be bothered by a USB-to-SPDIF converter as well as bandwidth since Blu Mk2's USB input will be capable of DXD and DSD512 playback.
Obviously, this galvanic isolation applies only when connected to DAVE.