I use my Omegas in my home office and on top of my large desk in a near field configuration and so regardless of room size, the impact of the room has less bearing. Unlike my large Sonus Faber Cremonas (which are mid field) and are heavy and spiked to the floor, these speakers are easy to toe in or toe out which provides me easy flexibility in terms of varying my soundstage to my preference. Properly toed in, I can opt for more pinpoint imaging but with some minor adjusting, I can easily increase my soundstage (both depth and width) by bringing more of the room into play. This is something that is not possible with headphones nor is it practical with larger speakers.
The Omegas sit on IsoAcoustic Aperta stands to minimize reflections from my desk. I use a Symposium Acoustic Svelte Plus platform in between the Aperta stands and my Omegas and I have found these to very effectively dampen unwanted resonances from my speaker enclosures while providing further decoupling from my desk. I have found them to be more effective than Stillpoints. This combination of platforms perfectly elevates the Alnico drivers to ear level. While I enjoy my Sonus Fabers, I enjoy these much more.
For mid field or far field configurations, especially in larger rooms, my compact Omegas will work although I would suggest the larger Omega Super Alnico towers. They maintain the same high efficiency as my smaller monitors but their larger cabinets can obviously move more air. For large rooms, I have yet to hear anything as alluring to my personal sensibilities as the Voxativ 9.87s. They utilize wood cones that are of even higher efficiency. They can be fitted with ferrite or Alnico magnets. Field coil configuration is also an option depending on the sound signature you're after. I have found it much to my preference to tune mostly at the speaker level and have my amp and my sources remains as neutral and transparent as possible. This is much easier to do with speakers given the greater number of options although it's nice to see high-end headphone options increasing. I am eager to hear how Voxativ's upcoming headphones will sound.
The nice thing about working with small companies like Omega or Voxativ is that these speakers can be custom configured much more easily. Not easy to do with large companies like Sony, B&W, Focal, etc. With my Omegas, for example, Louis Chochos (the owner) was willing to alter the dimensions of my monitors to my preference so that they fit perfectly in my space. His only requirement was that I maintain a certain volume. He further accommodated my preference for a certain pair of low mass Furutech binding posts as well as internal speaker wire (OCC silver/gold alloy). Because he builds to order and sells direct, I'm sure I would have paid almost double if I had to buy through a dealer and so these speakers cost less than most of my headphones.