Try a different usb port, one at the back of the pc. Or try other usb cables, Or try using Foobar and adjust the output buffer length. Make sure no process is grabbing most of the CPU or usb bandwidth. I am on Windows 10, formerly on Window 7, no issue, whatever the software i use. My music is on the internal disk, so usb is not much sollicited. My guess is the usb port you use is noisy ou you have an issue with you pc or os, Foobar allows obtaining exlusive access to the device, which is a good idea to maximize sound quality.