This is a hand-drawn frame in colored pencil. In the process, the artists draw up the genga, then like a lead animator makes the corrections as seen above. Ah I'll just paste info from a web site I had seen:
"Once the storyboards are finalized, cuts are divided up among the key animators who create roughs, layouts and eventually genga and key frames. From there, the specification supervisor will do another set of drawings to touch up the genga work and make sure everything is on model. These sheets are then sent out to the 'tweeners who create douga for each frame. Meanwhile, the background specs are sent off to a different person or perhaps a different production house in order to have the backgrounds created. I think in general these separate people also need the douga in order to make sure the backgrounds they created will align themselves properly. The douga is used to photocopy black lines onto acetate. From there, cel painters splotch single colors on at a time according to speculation. When all of this is finished and dried, the cels are sent back to be checked and filmed. Sometimes things are not adequately checked or even adequately dried before filming."