Silver, I currently own both the 22 and the 5, and upgraded from the 6 SE.
The 22 can sound a bit clinical depending on tubes. I actually preferred the 6SE initially until I changed out the stock tubes. The reason for buying the 22 was to run a balanced system, and I found that with a balanced source and the tube upgrades, the system became tonally neutral and a tad warmer in the mid range, and bettered the 6 SE.
But then came the 5. It is not balanced, and while the stock tubes can be improved without too much expense, the 5 sounded magnificent out of the gate and only improved with tube rolling. The 5 was capable of handling any headphone I threw at it. Mine had the upgraded caps.
The 5 sounds big, powerful, lush and with terrific balance. In hindsight I should have just bypassed the 22, because factoring in having to upgrade tubes and balanced cables, the cost was about the same as the stock 5.
Too be clear, this is not a slam of the 22, which continues to sound wonderful but primarily on a fully balanced system using Sennheisers and Focal Clears. Rather, the 5 excels with many sources, and all headphones. I’ve replaced the 300b tubes with Genelecs and the rectifier and the sound improved but not quite as dramatically as the 22.