Can't contribute to comparisons with other TOTL iems like W60 and Shure se846, because UM Pro 50 is my first venture in the high end headphones. I own a pair of se215. And what I can tell you is that UM Pro 50 is a clear upgrade in every way.
I'm not an expert so can't give you specifics, but sound-wise it's really great. Voices are so clear and the lows have so much more finesse. Soundstage is much wider. The only thing se215 comes close in is the lack of harshness. But that doesn't matter since my shures are much less comfortable than UM Pro 50, so you can't listen to them for long periods. They are just too big and the design itself wouldn't permit them to be as comfy as the westones even if they were smaller, in my opinion. I was completely blown away by how comfortable UM Pro 50 is! That both for the outer ear and the inner cannel with silicone tips. I didn't know that it was possible for universal iems to be this easy to wear and forget they're even on. They are also much easier to put on and take off as a result, which is also partially owing to the cable that come with them.
Sorry that I can't draw comparisons to the ones you mentioned or at least with iems in the category you have been listening to. I can't tell you that you'll be as amazed with the sound as I was, seeing that you're coming from mid-end iems. I do believe though that if you go with UM Pro 50 you'll find them much more fitting and comfortable than anything you've ever owned. Also after reading the reviews, it looks like UM Pro 50 and W60 are very similar in sound quality, but the former is cheaper by more than 300 bucks. Although you don't get those fancy faceplates and extra cable of W60, I find the UM Pro 50 a better value for the money, if the sound signature is indeed similar as the reviews suggest.