V281 is less warm than the V280 with a slightly bigger soundstage, you also have the power advantage. Can't say anything about those DACs in comparison though. However if you have the money then go for the V850. Much more sophisticated build and a superior PSU.
Having run a V281 with an Auralic Vega, then a Hegel HD30, and now a Bricasti M1, I can confirm that this amp scales nicely with better DACs. I have never heard the V850 - might be great for all I know - but if your budget can stretch to an Uber-ish DAC, the V281 will reward you.
My original V281 was damaged in a power spike and is under repair. I missed it so much I picked up a replacement unit on a recent trip to Melbourne to visit family. The price was too good to miss. Only downside is that only the silver face plate option was available, but it has the TOTL relay volume control. Since I don't look at the DAC while listening to music I really don't care all that much about the colour. Not sure what to do with the extra V281 once the repair is complete. Might just keep it as a spare since I don't like to be without a working V281.
Some folks have asked about running a HE6 from the V281 and the gain switches at the back. My 2 cents on this - the V281 drives the HE6
superbly. I am using my V281->HE6 rig right now. The volume control is at 12 o'clock and putting it higher will start listening fatigue for me. The XLR outputs on my Bricasti throw about 3V, so the DAC feed is slightly warm, but there is plenty of head space on the amp. This is with the gain switches in the default position (no extra gain at all). It just isn't necessary IMHO, even with the HE6.
A DAC with a 2V output would need the volume pot cranked a little more, but messing with the gain switches still shouldn't be necessary. This is using the balanced output on the V281, of course. I think the single ended outputs throw half the power? Whatever - pointless with the HE6. Go balanced or go home
Running the HE6 from a power amp does give
slightly more bass and body to the music to my ears, but not hugely so in my experience. Maybe a 5 or 10% difference, if that. I think it would not be a simple task to tell them apart in a blind test. My HE6 slams hard from the V281.
I have gone through the Auralic Taurus MK2, then Simaudio 430HA and finally the V281. My amp search has ended with the V281. I love this amp.