I listen to a lot of electronica (breakcore, drill n bass, idm, ambient) and I recently upgraded from HFI580s to PRO550s (only about 50hrs of burn in so far, so I guess they need a little more time to reach their full potential).
If you're all about the quantity of bass and the 780s are anything like the 580s then I'd say go with the 780s. PRO550s have a little less bass, but they're more detailed, the soundstage is also much bigger, and they're also much better with female vocals. I'd say that they handle "busy" music with much more ease than the HFIs. From what I've read, the PRO650s (just like the HFI680s) are considered to be the most balanced of the bunch, so it'd be my guess that they're even less bassy.
When it comes to comfort, I find that the headband padding is equally bad on all Ultrasones and it will probably dig into your skull after a while. I just use the padding I ripped off my DR150s. The earpads in the PRO series are bigger, deeper, a lot more comfortable than the ones used in the HFIs. The material the 550s and 650s use is also more pleasant to the touch, but I guess that's up to personal taste -- personally I'm not a big fan of pleather. The HFIs isolate a little better.
I'm talking about slightly different cans, but I hope some of this helps.
btw, you might want to read this:
http://www.head-fi.org/forum/thread/86109/tested-and-compared-ultrasone-proline-550-650-and-750-the-hfi-550-and-650