The differences that one will notice is based on the individual's hearing, experiences and other factors: I let my GF and her friends listen to my HD650 on a BH Crack, Fiio X3ii, Ember, iPhone 6S and Galaxy S5. Between the S5 and 6S none of the girls noticed any differences mostly due to the fact that neither phone could get the HD650 to listening levels at max volume. Changing over to the BH Crack, X3ii and Ember only one person could tell the difference between the 3 different amps, me. My GF and her 3 friends all think the HD650 sounds the same on the 3 different amps but as soon as I gave them hints on what to listen for they started to notice the difference but even then they all say its so slight that the majority would never notice the difference in the real world. The good thing is they noticed the differences in various headphones and with some headphones like the HD800, HE560 and EL-8 they notice the differences on different amps which makes sense since these headphones sound signature are more influenced with the choice of amp.
Moral of the story, what is a "huge, large, very noticeable" difference to most Head-Fi members with some headphones might / would be considered inaudible to most of the general population unless its volume level differences, then pretty much all will notice it.