Have to say, their isolation is very very good although ironically their claims of new technology to make them even more comfy for long use are kind of moribund due to the tight squeeze on the head! (and I have a small head)
The HD 280 Pro also had a monster clamp on my noggin, so their design similarities + your impressions of the sound so far make me think of these HD 300 Pro as more of an update to the HD 280 Pro - perhaps just as its model number suggests! - rather than as a modern take on the HD 250 as Sennheiser claims.