Interesting, So if there is an audio change like that, that means the isolator is over filtering the power and causing the return currents from the analog side not to be equal across different frequency. But its not much of a circuit.

Its very minimal for one of these, But a better designed isolator will Isolate, and allow a better power supply to replace the usb power entirely. Alot of people don't understand, that the current capacity of the usb port is the #1 issue here. Jitter is a secondary symptom when it is present in the usb circuit. But here is the standard industrial version. Here we not only isolate ~1500V , but also replace the usb power entirely:
Jitter, on the usb isn't going to be critical, its Jitter in the DAC. If the clocking of the DAc or what is referred to as the clock-master is in the computer, the clocking will never be accurate primarily because the 99% of the clocks in modern computers are not stable. In the pro audio world, we usually clock the converters independently from the computer. Some go to the extreme here in their clocking setups to the point of deriving the sample rate clock from a 10Mhz iridium (atomic) clock.