I have a Computer > Modi 3+> Vali 2+> Klipsch powered speakers. I use it for online concerts and playing ripped files. The addition of the Vali in front of the powered Klipsch speakers was noticeable, but subtle. The sound became "smoother." I do not know how to define "smoother", but that is what happened. I started with the original tube and then rolled it to an Electro-Harmonix E88CC. That change was also subtle, the upper bass notes (trombone, or the lower strings on a 6-string guitar) became clearer. I did not notice any other effect.
I have also used the combination CD player > Modi 3+> Vali 2+ > Ancient Magnavox tube amp. I eventually replaced the Vali with a Saga. I am still deciding what effect I hear. The sound has changed, but I am at a loss to say exactly what changed.
So with your desktop setup you are adjusting the volume via the Vali 2 or Klipsch speakers? For me it would be a pain to get up every time I wanted to change the volume. My stereo setup is for both movies and music in my "man cave". So I would be adjusting the volume on the integrated stereo amp. I would need to set the volume and gain on the Vali 2 and leave it alone. What would be the best setting to put it at?