I used to have a case with only one fan, but the entire inside of that case had gotten so hot that some of the internal computer components housed within failed. The last time I checked the entire interior of that case exceeded 75 degrees Celsius/167 degrees Fahrenheit!
And that was at a time when I had a 2MB PCI video card, a P133MHz (not even a PII!) processor with only 32MB of EDO memory (not even SDRAM!), a 540MB 3600RPM HD, a 2X CD-ROM drive (no DVD or CD-R/RW drive), and *coughMicrosoftcough* Windows 3.1!
Which comes to show you that some of the one-fan cases are poorly designed.
Anywhoo, my *current* case is a side-open and tool-less case that originally shipped with no fan whatsoever other than the *noisy* one within its 250W PSU - and there is a gaping hole in the rear of the case to accomodate an 80mm fan. I have added an 80mm fan (installed in that gaping hole in the rear of the case, and oriented to blow air
outward instead of inward) - and with my current system being a PIII-700 with 256MB of SDRAM on a 440BX-chipset-based motherboard, a Radeon 64MB DDR AGP card, a 40GB 7200RPM HD, both an 8X/40X DVD/CD-ROM drive and a 24X/10X/40X CD-RW drive, and now a 300W PSU with a much quieter fan (my PIII-700 processor is a "retail-boxed" processor with its own fan and heatsink), my system (at motherboard level) barely exceeds 27 degrees Celsius/80 degrees Fahrenheit. And these days, my OS of choice is either Windows 98SE or Windows ME.